UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes

被引：18

作者：

de Souza, Robson F. ^{[1
]}

Aravind, L. ^{[1
]}

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

来源：

BIOINFORMATICS | 2010年 / 26卷 / 12期

基金：

美国国家卫生研究院;

关键词：

ESCRT-I; MEMBRANE-PROTEINS; DENN;

D O I：

10.1093/bioinformatics/btq235

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions of the ESCRT complexes are critical for endosomal trafficking. We identify two domains with potential significance for this process. The MABP domain present in metazoan ESCRT-I/MVB12 subunits, Crag, a regulator of protein sorting, and bacterial pore-forming proteins might mediate novel membrane interactions in trafficking. The UBAP1-MVB12-associated UMA domain found in MVB12 and UBAP1 defines a novel adaptor that might recruit diverse targets to ESCRT-I.

引用

页码：1477 / 1480

页数：4

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