Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses

被引:49
作者
Shoemaker, JK
Hogeman, CS
Silber, DH
Gray, K
Kerr, M
Sinoway, LI
机构
[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Cardiol Sect, Hershey, PA 17033 USA
[2] Lebanon Vet Affairs Med Ctr, Lebanon, PA 17042 USA
关键词
forearm blood flow; vascular conductance; muscle sympathetic nerve activity; reactive hyperemia;
D O I
10.1152/jappl.1998.84.5.1756
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To test the hypothesis that head-down-tilt bed rest (HDBR) for 14 days alters vascular reactivity to vasodilatory and vasoconstrictor stimuli, the reactive hyperemic forearm blood flow (RHBF, measured by venous occlusion plethysmography) and mean arterial pressure (MAP, measured by Finapres) responses after 10 min of circulatory arrest were measured in a control trial (n = 20) and when sympathetic discharge was increased by a cold presser test (RHBF + cold presser test; n = 10). Vascular conductance (VC) was calculated (VC = RHBF/MAP). In the control trial, peak RHBF at 5 s after circulatory arrest (34.1 +/- 2.5 vs. 48.9 +/- 4.3 ml.100 ml(-1).min(-1)) and VC (0.34 +/- 0.02 vs. 0.53 +/- 0.05 ml.100 ml(-1).min(-1).mmHg(-1)) were reduced in the post-compared with the pre-HDBR tests (P < 0.05). Total excess RHBF over 3 min was diminished in the post-compared with the pre-HDBR trial (84.8 vs. 117 ml/100 ml, P < 0.002). The ability of the cold presser test to lower forearm blood flow was less in the post-than in the pre-HDBR test (P < 0.05), despite similar increases in MAP. These data suggest that regulation of vascular dilation and the interaction between dilatory and constrictor influences were altered with bed rest.
引用
收藏
页码:1756 / 1762
页数:7
相关论文
共 37 条
[1]  
Arbeille P, 1996, MED SCI SPORT EXER, V28, pS70
[2]   THE ABOLITION OF REACTIVE AND POST-EXERCISE HYPERAEMIA IN THE FOREARM BY TEMPORARY RESTRICTION OF ARTERIAL INFLOW [J].
BLAIR, DA ;
GLOVER, WE ;
RODDIE, IC .
JOURNAL OF PHYSIOLOGY-LONDON, 1959, 148 (03) :648-658
[3]  
Blatteis C.M., 1996, HDB PHYSL 4, VII, P815, DOI [DOI 10.1002/CPHY.CP040236, 10.1002/cphy.cp040236]
[4]   Orthostatic intolerance after spaceflight [J].
Buckey, JC ;
Lane, LD ;
Levine, BD ;
Watenpaugh, DE ;
Wright, SJ ;
Moore, WE ;
Gaffney, FA ;
Blomqvist, CG .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 81 (01) :7-18
[5]   THE ROLE OF MYOGENIC RELAXATION, ADENOSINE AND PROSTAGLANDINS IN HUMAN FOREARM REACTIVE HYPEREMIA [J].
CARLSSON, I ;
SOLLEVI, A ;
WENNMALM, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1987, 389 :147-161
[6]   METABOLIC AND HEMODYNAMIC EFFECTS OF PROLONGED BED REST IN NORMAL SUBJECTS [J].
CHOBANIAN, AV ;
LILLE, RD ;
TERCYAK, A ;
BLEVINS, P .
CIRCULATION, 1974, 49 (03) :551-559
[7]   VO2 KINETICS OF CONSTANT-LOAD EXERCISE FOLLOWING BED-REST-INDUCED DECONDITIONING [J].
CONVERTINO, VA ;
GOLDWATER, DJ ;
SANDLER, H .
JOURNAL OF APPLIED PHYSIOLOGY, 1984, 57 (05) :1545-1550
[8]   Evidence for increased beta-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans [J].
Convertino, VA ;
Polet, JL ;
Engelke, KA ;
Hoffler, GW ;
Lane, LD ;
Blomqvist, CG .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 273 (01) :R93-R99
[9]   EFFECT OF SIMULATED MICROGRAVITY ON CARDIOPULMONARY BAROREFLEX CONTROL OF FOREARM VASCULAR-RESISTANCE [J].
CONVERTINO, VA ;
DOERR, DF ;
LUDWIG, DA ;
VERNIKOS, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (06) :R1962-R1969
[10]   RAT AORTIC VASOREACTIVITY IS ALTERED BY OLD-AGE AND HINDLIMB UNLOADING [J].
DELP, MD ;
BROWN, M ;
LAUGHLIN, MH ;
HASSER, EM .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (06) :2079-2086