Vulnerability of the endocrine system to xenobiotic influence

Natural sex hormones are most important factors guaranteeing the homeostasis of male and female sexual functions, including sexual differentiation and reproduction. Main target tissues include bone and skin, cardiovascular system, and possibly central nervous and immune systems. In medicine, synthetic hormonal substances with agonistic and antagonistic properties have been widely used for decades. Therapeutic benefit is the aim, and the many possibilities to interfere with normal or pathological hormonal situations are rather well understood. Synthetic hormonal agonists or (partial) antagonists may exhibit specific affinities to special receptors resulting in a spectrum of organotropies, or they may even induce opposite actions on different targets. Although not a new issue, environmental substances mimicking potentials of sex hormones have recently gained increased attention. There is no need to reinvent the wheel, since most (adverse) effects may be revealed with today's routine procedures used for testing medicinal substances, but some additional testing strategies should be included. Adverse effects of ecohormones may preferentially affect systems other than the human organism (assuming lower exposure and possibly lower susceptibility). Nevertheless, this survey is confined to possible alterations in the mammalian organism, since such effects are best understood from numerous experimental studies and clinical trials. (C) 1997 Academic Press.