Trapping of the C5 methylene intermediate in thymidylate synthase

被引：30

作者：

Barrett, JE

Maltby, DA

Santi, DV

Schultz, PG ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 02期

关键词：

D O I：

10.1021/ja973210t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：449 / 450

页数：2

共 14 条

[1] THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE [J].

CARRERAS, CW ;

SANTI, DV .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :721-762

[2] WATER-MEDIATED SUBSTRATE/PRODUCT DISCRIMINATION - THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83-ANGSTROM [J].

FAUMAN, EB ;

RUTENBER, EE ;

MALEY, GF ;

MALEY, F ;

STROUD, RM .

BIOCHEMISTRY, 1994, 33 (06) :1502-1511

[3]

HUANG WD, 1994, J BIOL CHEM, V269, P31327

[4] A CHEMICAL-MODEL FOR THE FRAGMENTATION REACTION IN THYMIDYLATE SYNTHASE CATALYSIS - SYNTHESIS AND EVALUATION OF A 5-METHYLENE-1-(1,2,3,4-TETRAHYDROQUINOLYL)-6-ALLYLURIDINE [J].

KAGEL, JR ;

WANG, BH ;

MERTES, MP .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (10) :2738-2746

[5] ROLE OF THE CONSERVED TRYPTOPHAN-82 OF LACTOBACILLUS-CASEI THYMIDYLATE SYNTHASE [J].

KEALEY, JT ;

ECKSTEIN, J ;

SANTI, DV .

CHEMISTRY & BIOLOGY, 1995, 2 (09) :609-614

[6] ON THE MECHANISM OF 2'-DEOXYURIDYLATE HYDROXYMETHYLASE [J].

KUNITANI, MG ;

SANTI, DV .

BIOCHEMISTRY, 1980, 19 (07) :1271-1275

[7] CRYSTAL-STRUCTURE OF ESCHERICHIA-COLI THYMIDYLATE SYNTHASE CONTAINING BOUND 5-FLUORO-2'-DEOXYURIDYLATE AND 10-PROPARGYL-5,8-DIDEAZAFOLATE [J].

MATTHEWS, DA ;

APPELT, K ;

OATLEY, SJ ;

XUONG, NH .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (04) :923-936

[8] STEREOCHEMICAL MECHANISM OF ACTION FOR THYMIDYLATE SYNTHASE BASED ON THE X-RAY STRUCTURE OF THE COVALENT INHIBITORY TERNARY COMPLEX WITH 5-FLUORO-2'-DEOXYURIDYLATE AND 5,10-METHYLENETETRAHYDROFOLATE [J].

MATTHEWS, DA ;

VILLAFRANCA, JE ;

JANSON, CA ;

SMITH, WW ;

WELSH, K ;

FREER, S .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (04) :937-948

[9] STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMMODATION IN THYMIDYLATE SYNTHASE ON BINDING DUMP AND AN ANTIFOLATE [J].

MONTFORT, WR ;

PERRY, KM ;

FAUMAN, EB ;

FINERMOORE, JS ;

MALEY, GF ;

HARDY, L ;

MALEY, F ;

STROUD, RM .

BIOCHEMISTRY, 1990, 29 (30) :6964-6977

[10] AN ISOTOPIC ASSAY FOR THYMIDYLATE SYNTHETASE [J].

ROBERTS, D .

BIOCHEMISTRY, 1966, 5 (11) :3546-&

← 1 2 →