The Spectrum of MYH9-Associated Nephropathy

被引：64

作者：

Bostrom, Meredith A. ^{[2
]}

Freedman, Barry I. ^{[1
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Nephrol Sect, Dept Internal Med Nephrol, Winston Salem, NC 27157 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

STAGE RENAL-DISEASE; HEAVY-CHAIN IIA; 9 GENE MYH9; AFRICAN-AMERICANS; KIDNEY-DISEASE; HYPERTENSIVE NEPHROSCLEROSIS; FAMILIAL RISK; MUTATIONS; BLACKS; PROGRESSION;

D O I：

10.2215/CJN.08721209

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Causes of the excess incidence rates of chronic kidney disease in the African American population have long been under study. Recently, polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) have been associated with nondiabetic kidney diseases in African- and European-derived populations. Risk variants in MYH9 contribute to approximately 70% of nondiabetic forms of ESRD in African Americans and 40 to 45% of all ESRD in this ethnic group, with lesser effects in European Americans. It is clear that MYH9 polymorphisms have a significant impact on the incidence rates of kidney disease in African Americans. This article describes the current spectrum of biopsy-proven MYH9-associated kidney diseases, along with potential effects of MYH9 on ethnic differences in clinical outcome. MYH9 risk variants exhibit the most impressive association with any common complex kidney disease yet identified. Clin J Am Sac Nephrol 3: 1107-1113, 2010. doi: 10.2215/CJN.08721209

引用

页码：1107 / 1113

页数：7

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