BAFF: A fundamental survival factor for B cells

被引：552

作者：

Mackay, F

Browning, JL

机构：

[1] Garvan Inst Med Res, Dept Arthritis & Inflammat, Darlinghurst, NSW 2010, Australia

[2] Biogen Inc, Dept Immunol & Inflammat, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nri844

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B-cell-activating factor of the tumour-necrosis-factor family (BAFF) enhances B-cell survival a function that is indispensable for B-cell maturation - and has a role in enhancing immune responses. Moreover, the overexpression of BAFF results in severe autoimmune disorders in mice, and elevated serum levels of BAFF occur in some patients who have autoimmune diseases. The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease.

引用

页码：465 / 475

页数：11

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