Genome editing with engineered zinc finger nucleases

被引：1549

作者：

Urnov, Fyodor D. ^{[1
]}

Rebar, Edward J. ^{[1
]}

Holmes, Michael C. ^{[1
]}

Zhang, H. Steve ^{[1
]}

Gregory, Philip D. ^{[1
]}

机构：

[1] Sangamo BioSci Inc, Richmond, CA 94804 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 09期

关键词：

TRANSCRIPTION FACTOR IIIA; TARGETED GENE ADDITION; DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; CRYSTAL-STRUCTURE; DNA RECOGNITION; BINDING DOMAINS; KNOCKOUT RATS; PLANT-CELLS; STEM-CELLS;

D O I：

10.1038/nrg2842

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Reverse genetics in model organisms such as Drosophila melanogaster, Arabidopsis thaliana, zebrafish and rats, efficient genome engineering in human embryonic stem and induced pluripotent stem cells, targeted integration in crop plants, and HIV resistance in immune cells-this broad range of outcomes has resulted from the application of the same core technology: targeted genome cleavage by engineered, sequence-specific zinc finger nucleases followed by gene modification during subsequent repair. Such 'genome editing' is now established in human cells and a number of model organisms, thus opening the door to a range of new experimental and therapeutic possibilities.

引用

收藏

页码：636 / 646

页数：11

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