Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma

被引：36

作者：

Cordano, P ^{[1
]}

Lake, A

Shield, L

Taylor, GM

Alexander, FE

Taylor, PRA

White, J

Jarrett, RF

机构：

[1] Univ Glasgow, Inst Comparat Med, LRF Virus Ctr, Glasgow G61 1QH, Lanark, Scotland

[2] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[3] Univ Manchester, Canc Immunogenet Lab, Manchester M13 9PL, Lancs, England

[4] Royal Victoria Infirm, Newcastle Upon Tyne, Tyne & Wear, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 128卷 / 04期

关键词：

IL-6; single nucleotide polymorphism; Hodgkin's lymphoma;

D O I：

10.1111/j.1365-2141.2004.05353.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.

引用

页码：493 / 495

页数：3

共 13 条

[1] An epidemiologic study of index and family infectious mononucleosis and adult Hodgkin's disease (HD):: Evidence for a specific association with EBV+ve HD in young adults [J].

Alexander, FE ;

Lawrence, DJ ;

Freeland, J ;

Krajewski, AS ;

Angus, B ;

Taylor, GM ;

Jarrett, RF .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (02) :298-302

[2] IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma [J].

Cozen, W ;

Gill, PS ;

Ingles, SA ;

Masood, R ;

Martínez-Maza, O ;

Cockburn, MG ;

Gauderman, WJ ;

Pike, MC ;

Bernstein, L ;

Nathwani, BN ;

Salam, MT ;

Danley, KL ;

Wang, W ;

Gage, J ;

Gundell-Miller, S ;

Mack, TM .

BLOOD, 2004, 103 (08) :3216-3221

[3] Comprehensive human genome amplification using multiple displacement amplification [J].

Dean, FB ;

Hosono, S ;

Fang, LH ;

Wu, XH ;

Faruqi, AF ;

Bray-Ward, P ;

Sun, ZY ;

Zong, QL ;

Du, YF ;

Du, J ;

Driscoll, M ;

Song, WM ;

Kingsmore, SF ;

Egholm, M ;

Lasken, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5261-5266

[4] The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis [J].

Fishman, D ;

Faulds, G ;

Jeffery, R ;

Mohamed-Ali, V ;

Yudkin, JS ;

Humphries, S ;

Woo, P .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1369-1376

[5]

Foster CB, 2000, BLOOD, V96, P2562

[6]

GAUSE A, 1992, LYMPHOKINE CYTOK RES, V11, P109

[7] Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study [J].

Georges, JL ;

Loukaci, V ;

Poirier, O ;

Evans, A ;

Luc, G ;

Arveiler, D ;

Ruidavets, JB ;

Cambien, F ;

Tiret, L .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2001, 79 (5-6) :300-305

[8]

Herbst H, 1997, J PATHOL, V182, P299, DOI 10.1002/(SICI)1096-9896(199707)182:3<299::AID-PATH856>3.0.CO

[9]

2-8

[10] The Scotland and Newcastle epidemiological study of Hodgkin's disease: impact of histopathological review and EBV status on incidence estimates [J].

Jarrett, RF ;

Krajewski, AS ;

Angus, B ;

Freeland, J ;

Taylor, PR ;

Taylor, GM ;

Alexander, FE .

JOURNAL OF CLINICAL PATHOLOGY, 2003, 56 (11) :811-816

← 1 2 →