One degree of freedom for dominance in indirect association studies

被引：5

作者：

Chapman, Juliet

Clayton, David

机构：

[1] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

[2] Univ Cambridge, Cambridge Inst Med Res, Diabet & Inflammat Lab, Cambridge CB2 1TN, England

来源：

GENETIC EPIDEMIOLOGY | 2007年 / 31卷 / 03期

基金：

英国医学研究理事会;

关键词：

tag SNPs; dominance; association studies; power;

D O I：

10.1002/gepi.20207

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Usual tests of association using tag single nucleotide polymorphisms (SNPs) assume that the alleles of the causal locus act additively and that these alleles are then predicted indirectly via a set of tag SNPs. In the presence of strong dominance effects this model is not correct and an extra term needs to be included, which uses the tag SNPs to predict the heterozygosity of the causal locus. Assuming this scenario of a strong dominance effect, we present an appropriate test statistic and investigate how much power, if any, we gain by adding this single degree of freedom for dominance.

引用

收藏

页码：261 / 271

页数：11

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