Quaternary substituted PDE IV inhibitors II:: The synthesis and in vitro evaluation of a novel series of γ-lactams

被引：12

作者：

Hulme, C

Moriarty, K

Huang, FC

Mason, J

McGarry, D

Labaudiniere, R

Souness, J

Djuric, S

机构：

[1] Rhone Poulenc Rorer Cent Res, Collegeville, PA 19426 USA

[2] Rhone Poulenc Rorer Cent Res, Dagenham, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(98)00036-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE TV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50's for PDE IV inhibition. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：399 / 404

页数：6

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