How colonization by microbiota in early life shapes the immune system

被引：1588

作者：

Gensollen, Thomas ^{[1
]}

Iyer, Shankar S. ^{[1
]}

Kasper, Dennis L. ^{[2
]}

Blumberg, Richard S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Div Gastroenterol Hepatol &, Boston, MA USA

[2] Harvard Univ, Sch Med, Div Immunol, Dept Microbiol & Immunobiol, Boston, MA USA

来源：

SCIENCE | 2016年 / 352卷 / 6285期

关键词：

REGULATORY T-CELLS; GERM-FREE MICE; INNATE LYMPHOID-CELLS; INTESTINAL INTRAEPITHELIAL LYMPHOCYTES; INFANT GUT MICROBIOME; ANTIBIOTIC EXPOSURE; BACTERIAL-COLONIZATION; EOSINOPHILIC ESOPHAGITIS; DIFFERENTIAL INDUCTION; COMMENSAL MICROBIOTA;

D O I：

10.1126/science.aad9378

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing to the development of disease in later life, including inflammatory bowel disease, allergy, and asthma. Recent studies have begun to define a critical period during early development in which disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets. Here, we discuss the role of early-life education of the immune system during this "window of opportunity," when microbial colonization has a potentially critical impact on human health and disease.

引用

页码：539 / 544

页数：6

共 100 条

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