Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsy

被引:146
作者
Paviour, DC
Price, SL
Stevens, JM
Lees, AJ
Fox, NC
机构
[1] UCL, Inst Neurol, Sara Koe PSP Res Ctr, London WC1, England
[2] UCL, Dementia Res Ctr, London, England
[3] Natl Hosp Neurol & Neurosurg, Dept Clin Neuroradiol, London WC1N 3BG, England
基金
英国医学研究理事会;
关键词
D O I
10.1212/01.WNL.0000151854.85743.C7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Postmortem studies have shown atrophy of the superior cerebellar peduncle (SCP) to distinguish progressive supranuclear palsy (PSP) from other neurodegenerative diseases. It is not clear whether MRI-based measurements can differentiate this relative atrophy of the SCP during life. Methods: Volumetric MRI was acquired prospectively in 53 subjects: 19 with PSP, 10 with multiple system atrophy (MSA), 12 with Parkinson disease (PD), and 12 healthy controls. SCP volume was assessed by detailed quantitative volumetric measurement and independently by blinded visual rating of SCP atrophy. Results: The mean SCP volume, corrected for total intracranial volume, was lower in patients with PSP than controls (p = 0.001), patients with MSA (p = 0.001), and patients with PD (p = 0.003). There was an overlap between individual SCP volume measurements in the PSP subjects and the other groups. Neuroradiologic rating correctly identified PSP cases based on the presence of SCP atrophy with a sensitivity of 74% and a specificity of 94%. Conclusions: The authors propose that together with other radiologic features of progressive supranuclear palsy ( PSP) such as midbrain atrophy, a visual assessment of the superior cerebellar peduncle may help increase the clinical diagnostic accuracy in PSP.
引用
收藏
页码:675 / 679
页数:5
相关论文
共 28 条
[1]  
BARNES J, 2004, DIFFERENTIATING AD A
[2]  
Cubo E, 2000, MOVEMENT DISORD, V15, P276, DOI 10.1002/1531-8257(200003)15:2<276::AID-MDS1010>3.0.CO
[3]  
2-Q
[4]   PARKINSON PLUS SYNDROME - DIAGNOSIS USING HIGH-FIELD MR IMAGING OF BRAIN IRON [J].
DRAYER, BP ;
OLANOW, W ;
BURGER, P ;
JOHNSON, GA ;
HERFKENS, R ;
RIEDERER, S .
RADIOLOGY, 1986, 159 (02) :493-498
[5]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[6]   Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans [J].
Freeborough, PA ;
Fox, NC ;
Kitney, RI .
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 1997, 53 (01) :15-25
[7]   Consensus statement on the diagnosis of multiple system atrophy [J].
Gilman, S ;
Low, PA ;
Quinn, N ;
Albanese, A ;
Ben-Shlomo, Y ;
Fowler, CJ ;
Kaufman, H ;
Klockgether, T ;
Lang, AE ;
Lantos, PL ;
Litvan, I ;
Mathias, CJ ;
Oliver, E ;
Robertson, D ;
Schatz, I ;
Wenning, GK .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 163 (01) :94-98
[8]   PRELIMINARY NINDS NEUROPATHOLOGIC CRITERIA FOR STEELE-RICHARDSON-OLSZEWSKI SYNDROME (PROGRESSIVE SUPRANUCLEAR PALSY) [J].
HAUW, JJ ;
DANIEL, SE ;
DICKSON, D ;
HOROUPIAN, DS ;
JELLINGER, K ;
LANTOS, PL ;
MCKEE, A ;
TABATON, M ;
LITVAN, I .
NEUROLOGY, 1994, 44 (11) :2015-2019
[9]   PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].
HOEHN, MM ;
YAHR, MD .
NEUROLOGY, 1967, 17 (05) :427-&
[10]   The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service [J].
Hughes, AJ ;
Daniel, SE ;
Ben-Shlomo, Y ;
Lees, AJ .
BRAIN, 2002, 125 :861-870