Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy

被引：127

作者：

Gruettner, Cordula

Mueller, Knut

Teller, Joachim

Westphal, Fritz

Foreman, Allan

Ivkov, Robert

机构：

[1] Micromod Partikeltechnol GmbH, D-18119 Rostock, Germany

[2] Triton Biosyst Inc, Chelmsford, MA USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

关键词：

magnetic nanoparticle; hyperthermia; antibody conjugation; specific power absorption rate; cancer therapy; alternating magnetic field;

D O I：

10.1016/j.jmmm.2006.10.1151

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20-100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immuno reactivity of the final antibody-particle conjugate. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：181 / 186

页数：6

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