ANChors away: an actin based mechanism of nuclear positioning

被引：182

作者：

Starr, DA ^{[1
]}

Han, M

机构：

[1] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

[2] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

JOURNAL OF CELL SCIENCE | 2003年 / 116卷 / 02期

关键词：

nuclear migration; nuclear anchorage; UNC-84; SUN domain; ANG-1; muscular dystrophy; nuclear envelope;

D O I：

10.1242/jcs.00248

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mechanisms for nuclear migration and nuclear anchorage function together to control nuclear positioning. Both tubulin and actin networks play important roles in nuclear positioning. The actin cytoskeleton. has been shown to position nuclei in a variety of systems from yeast to plants and animals. It can either act as a stable skeleton to anchor nuclei or supply the active force to move nuclei. Two C elegans genes and their homologues play important roles in these processes. Syne/ANC-1 anchors nuclei by directly tethering the nuclear envelope to the actin cytoskeleton, and UNC-84/SUN functions at the nuclear envelope to recruit Syne/ANC-1.

引用

页码：211 / 216

页数：6

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