Alternative splicing as a regulator of development and tissue identity

被引：927

作者：

Baralle, Francisco E. ^{[1
]}

Giudice, Jimena ^{[2
,3
,4
]}

机构：

[1] ICGEB, Padriciano 99, I-34149 Trieste, Italy

[2] Univ North Carolina Chapel Hill, Dept Cell Biol & Physiol, Sch Med, Chapel Hill, NC 27599 USA

[3] Univ North Carolina Chapel Hill, McAllister Heart Inst, Chapel Hill, NC 27599 USA

[4] Univ North Carolina Chapel Hill, Curriculum Genet & Mol Biol, 111 Mason Farm Rd, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 07期

关键词：

RNA-BINDING PROTEINS; PROMOTES NEURONAL DIFFERENTIATION; DNA-METHYLATION; GENE-EXPRESSION; HNRNP-L; POSTTRANSCRIPTIONAL REGULATION; TRAFFICKING GENES; TRANSCRIPTION; PROGRAM; RBM20;

D O I：

10.1038/nrm.2017.27

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.

引用

收藏

页码：437 / 451

页数：15

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