Non-aqueous capillary electrophoresis of tamoxifen and its acid hydrolysis products

被引：30

作者：

Li, XF

Carter, SJ

Dovichi, NJ ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

[2] PE Sciex, MDS Hlth Grp, Concord, ON L4K 4V8, Canada

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 895卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

non-aqueous capillary electrophoresis; thermooptical absorbance detection; detection; electrophoresis; tamoxifen;

D O I：

10.1016/S0021-9673(00)00661-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tamoxifen and its acid hydrolysis products were separated and tentatively identified by non-aqueous capillary electrophoresis with thermooptical absorbance and electrospray ionization mass spectrometry. Acid hydrolysis is a convenient method of generating tamoxifen degradation products. The parent compound and seven hydrolysis products were separated in 9 min. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：81 / 85

页数：5

相关论文

共 20 条

[1] A realistic clinical perspective of tamoxifen and endometrial carcinogenesis [J].

Assikis, VJ ;

Neven, P ;

Jordan, VC ;

Vergote, I .

EUROPEAN JOURNAL OF CANCER, 1996, 32A (09) :1464-1476

[2] DETERMINATION OF TAMOXIFEN AND METABOLITES IN HUMAN-SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH POST-COLUMN FLUORESCENCE ACTIVATION [J].

BROWN, RR ;

BAIN, R ;

JORDAN, VC .

JOURNAL OF CHROMATOGRAPHY, 1983, 272 (02) :351-358

[3] DETERMINATION OF 2-METHYL DERIVATIVES OF TAMOXIFEN IN CELL-CULTURE MEDIUM USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ELECTROCHEMICAL DETECTION [J].

CHAMART, S ;

HANOCQ, M ;

HELSON, M ;

DEVLEESCHOUWER, N ;

LECLERCQ, G .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 496 (02) :365-375

[4] DETERMINATION OF TAMOXIFEN AND AN HYDROXYLATED METABOLITE IN PLASMA FROM PATIENTS WITH ADVANCED BREAST-CANCER USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY [J].

DANIEL, CP ;

GASKELL, SJ ;

BISHOP, H ;

NICHOLSON, RI .

JOURNAL OF ENDOCRINOLOGY, 1979, 83 (03) :401-408

[5]

DANIEL P, 1981, EUR J CANCER CLIN ON, V17, P1183

[6] THE PHARMACOLOGY AND CLINICAL USES OF TAMOXIFEN [J].

FURR, BJA ;

JORDAN, VC .

PHARMACOLOGY & THERAPEUTICS, 1984, 25 (02) :127-205

[7] QUANTITATIVE MEASUREMENT OF 4-HYDROXY TAMOXIFEN IN HUMAN PLASMA AND MAMMARY-TUMORS BY COMBINED GAS-CHROMATOGRAPHY NEGATIVE CHEMICAL-IONIZATION MASS-SPECTROMETRY [J].

GIRAULT, J ;

ISTIN, B ;

FOURTILLAN, JB .

BIOLOGICAL MASS SPECTROMETRY, 1993, 22 (07) :395-402

[8] HORMONAL CHEMOPREVENTION OF CANCER IN WOMEN [J].

HENDERSON, BE ;

ROSS, RK ;

PIKE, MC .

SCIENCE, 1993, 259 (5095) :633-638

[9]

Jordan V C, 1997, Oncology (Williston Park), V11, P7

[10] Preventing breast cancer with tamoxifen [J].

Jordan, VC .

HOSPITAL PRACTICE, 1998, 33 (09) :59-+