Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity

被引：38

作者：

Al-Swiahb, Jamil N. ^{[1
]}

Chen, Chang-Han ^{[1
,2
]}

Chuang, Hui-Ching ^{[1
]}

Fang, Fu-Min ^{[3
]}

Tasi, Hsin-Ting ^{[1
]}

Chien, Chih-Yen ^{[1
]}

机构：

[1] Chang Gung Univ, Chang Gung Mem Hosp, Kaohsiung Med Ctr, Coll Med,Dept Otolaryngol, Kaohsiung 833, Taiwan

[2] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Ctr Translational Res Biomed Sci, Kaohsiung, Taiwan

[3] Chang Gung Univ, Chang Gung Mem Hosp, Kaohsiung Med Ctr, Coll Med,Dept Radiat Oncol, Kaohsiung, Taiwan

来源：

FUTURE ONCOLOGY | 2010年 / 6卷 / 05期

关键词：

angiogenesis; array comparative genomic hybridization; carcinogenesis; metastasis; miRNA; oral cancer; prognosis; tumor suppressor; LYMPH-NODE INVOLVEMENT; PROGNOSTIC-SIGNIFICANCE; TONGUE CANCER; NECK-CANCER; CYCLIN D1; MATRIX METALLOPROTEINASE-2; CONSTITUTIVE ACTIVATION; TUMOR THICKNESS; RISK-FACTORS; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.2217/fon.10.35

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Squamous cell carcinoma of the oral cavity (OCSCC) is the most frequently observed form of head-and-neck cancer in Southeast Asia and is the sixth most common cancer worldwide. Most cases of this preventable disease are caused by alcohol consumption, smoking and betel nut chewing. The survival rates of patients with advanced OCSCC have not increased significantly in recent years. While treatments for OCSCC are similar worldwide, survival rates differ by geographical area. The various genetic profiles and individual genetic susceptibility for carcinogens may account for this discrepancy. In some respects, molecular alteration or accumulation affects tumor progression and the clinical outcomes among patients with OCSCC. Clarifying the tumor behavior of oral cancer, with regard to pathological features or molecular aspects, could help clinicians to judge, tailor and adopt more effective therapeutic strategies to treat oral cancer.

引用

页码：837 / 850

页数：14

共 150 条

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2-A

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