Ras proteins: Different signals from different locations

被引：677

作者：

Hancock, JF ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Dept Mol & Cellular Pathol, Brisbane, Qld 4072, Australia

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrm1105

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.

引用

页码：373 / 384

页数：12

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