Antibody-dependent enhancement of Ebola virus infection

被引：147

作者：

Takada, A ^{[1
]}

Feldmann, H

Ksiazek, TG

Kawaoka, Y

机构：

[1] Univ Tokyo, Div Virol, Dept Microbiol & Immunol, Inst Med Sci, Tokyo 1088639, Japan

[2] Japan Sci & Technol Corp, CREST, Saitama 3320012, Japan

[3] Canadian Sci Ctr Human & Anim Hlth, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

[4] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[5] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 13期

关键词：

D O I：

10.1128/JVI.77.13.7539-7544.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

引用

页码：7539 / 7544

页数：6

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