Isochlorogenic acid A attenuates acute lung injury induced by LPS via Nf-κB/NLRP3 signaling pathway

被引：21

作者：

Wang, Qin ^{[1
]}

Xiao, Li ^{[2
]}

机构：

[1] Hubei Univ Med, Renmin Hosp, Dept Pediat, Shiyan 442000, Hubei, Peoples R China

[2] Foshan Women & Children Hosp, Dept Pediat, 11 Ren Min Xi Rd, Foshan 528000, Guangdong, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2019年 / 11卷 / 11期

关键词：

Isochlorogenic acid A; acute lung injury; LPS; inflammation; oxidant stress; OXIDATIVE STRESS; RAT MODEL; INFLAMMATION; BIOMARKERS; EXTRACT; SERUM;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Nowadays, there is still no effective drug with small side effects for acute lung injury. Monomer of herb is promising for anti-inflammation therapy. In this study, we first investigated the possible effects of isochlorogenic acid A in acute lung injury induced by LPS. The effects of oxidant stress, pulmonary edema and inflammation factors induced by LPS were inhibited by isochlorogenic acid A. Levels of lung active markers and inflammation factors induced by LPS were reversed by isochlorogenic acid A. Isochlorogenic acid A inhibited the cell apoptosis induced by LPS. The protein expressions of Nf-kappa B/NLRP3 signaling pathway induced by LPS were inhibited by isochlorogenic acid A. In summary, isochlorogenic acid A reversed the effects induced by LPS in acute lung injury and is a promising monomer for therapy of acute lung injury, providing references for future research on therapy of acute lung injury.

引用

收藏

页码：7018 / 7026

页数：9

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