Synaptic computation

被引:1381
作者
Abbott, LF [1 ]
Regehr, WG
机构
[1] Brandeis Univ, Volcani Ctr, Waltham, MA 02454 USA
[2] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA
[3] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
D O I
10.1038/nature03010
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neurons are often considered to be the computational engines of the brain, with synapses acting solely as conveyers of information. But the diverse types of synaptic plasticity and the range of timescales over which they operate suggest that synapses have a more active role in information processing. Long-term changes in the transmission properties of synapses provide a physiological substrate for learning and memory, whereas short-term changes support a variety of computations. By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates.
引用
收藏
页码:796 / 803
页数:8
相关论文
共 75 条
  • [1] Abbott LF, 1997, SCIENCE, V275, P220, DOI 10.1126/science.275.5297.221
  • [2] [Anonymous], 2000, Principles of neural science
  • [3] Quantal currents at single-site central synapses
    Auger, C
    Marty, A
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2000, 526 (01): : 3 - 11
  • [4] Retinogeniculate synaptic properties controlling spike number and timing in relay neurons
    Blitz, DM
    Regehr, WG
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (04) : 2438 - 2450
  • [5] Enhancement of synaptic efficacy by presynaptic GABAB receptors
    Brenowitz, S
    David, J
    Trussell, L
    [J]. NEURON, 1998, 20 (01) : 135 - 141
  • [6] Minimizing synaptic depression by control of release probability
    Brenowitz, S
    Trussell, LO
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (06) : 1857 - 1867
  • [7] Brenowitz SD, 2003, J NEUROSCI, V23, P6373
  • [8] Timeline - The legacy of Donald O. Hebb: more than the Hebb synapse
    Brown, RE
    Milner, PM
    [J]. NATURE REVIEWS NEUROSCIENCE, 2003, 4 (12) : 1013 - 1019
  • [9] Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids
    Brown, SP
    Brenowitz, SD
    Regehr, WG
    [J]. NATURE NEUROSCIENCE, 2003, 6 (10) : 1048 - 1057
  • [10] Synaptic gain control and homeostasis
    Burrone, J
    Murthy, VN
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (05) : 560 - 567