T-cell potential and development in vitro:: the OP9-DL1 approach

被引：49

作者：

de Pooter, Rene ^{[1
]}

Zuniga-Pflucker, Juan Carlos ^{[1
]}

机构：

[1] Univ Toronto, Dept Immunol, Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 02期

关键词：

D O I：

10.1016/j.coi.2007.02.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.

引用

页码：163 / 168

页数：6

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