Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children

被引:40
作者
Malerba, G
Lauciello, MC
Scherpbier, T
Trabetti, E
Galavotti, R
Cusin, V
Pescollderungg, L
Zanoni, G
Martinati, LC
Boner, AL
Levitt, RC
Pignatti, PF
机构
[1] Univ Verona, Dept Mother & Child Biol & Genet, Sect Biol & Genet, I-37134 Verona, Italy
[2] Univ Verona, Dept Pathol, I-37134 Verona, Italy
[3] Magainin Pharmaceut, Plymouth Meeting, PA USA
[4] Hosp Balzano, Div Paediat, Bolzano, Italy
关键词
D O I
10.1164/ajrccm.162.4.9909031
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
We investigated 116 Italian atopic families (560 individuals) for linkage with 13 DNA markers on chromosome 12. All the subjects were phenotyped for asthma, total serum IgE, bronchial hyperresponsiveness, skin-prick positivity to common aeroallergens, and atopy. A relative location map of the markers was prepared from Centre d'Etude du Polymorphisme Humain families. Affected sib pair multipoint linkage methods were used to perform the statistical analyses. We report suggestive linkage for asthma with markers on chromosome 12. The region of interest centers around marker D12S390 (maximum logarithm of odds [mlod] = 2.81; p = 0.003). These results provide additional support that asthma susceptibility factors are located on chromosome 12q.
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收藏
页码:1587 / 1590
页数:4
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