Ductal Origin Hypothesis of Pancreatic Regeneration under Attack

被引：55

作者：

Kushner, Jake A. ^{[1
,2
,3
,4
]}

Weir, Gordon C. ^{[5
]}

Bonner-Weir, Susan ^{[5
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Endocrinol & Diabet, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[5] Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Islet Transplantat & Cell Biol, Boston, MA 02215 USA

来源：

CELL METABOLISM | 2010年 / 11卷 / 01期

关键词：

BETA-CELL REGENERATION; PROGENITORS; GROWTH; MICE;

D O I：

10.1016/j.cmet.2009.12.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although pancreatic beta cells are known to expand by self-renewal in postnatal life, contribution by ductal progenitors remains vigorously debated. In a recent issue of Developmental Cell, Jorge Ferrer and colleagues report lineage tracing studies that challenge the ductal origin hypothesis (Solar et al., 2010).

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收藏

页码：2 / 3

页数：2

相关论文

共 10 条

[1] All β cells contribute equally to islet growth and maintenance [J].

Brennand, Kristen ;

Huangfu, Danwei ;

Melton, Doug .

PLOS BIOLOGY, 2007, 5 (07) :1520-1529

[2] Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation [J].

Dor, Y ;

Brown, J ;

Martinez, OI ;

Melton, DA .

NATURE, 2004, 429 (6987) :41-46

[3] Cellular origins of β-cell regeneration: a legacy view of historical controversies [J].

Granger, A. ;

Kushner, J. A. .

JOURNAL OF INTERNAL MEDICINE, 2009, 266 (04) :325-338

[4] Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth [J].

Inada, Akari ;

Nienaber, Cameron ;

Katsuta, Hitoshi ;

Fujitani, Yoshio ;

Levine, Jared ;

Morita, Rina ;

Sharma, Arun ;

Bonner-Weir, Susan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (50) :19915-19919

[5] Recovery from diabetes in mice by β cell regeneration [J].

Nir, Tomer ;

Melton, Douglas A. ;

Dor, Yuval .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2553-2561

[6] A role for islet neogenesis in curing diabetes [J].

Pittenger, G. L. ;

Taylor-Fishwick, D. ;

Vinik, A. I. .

DIABETOLOGIA, 2009, 52 (05) :735-738

[7] Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan [J].

Rooman, I ;

Bouwens, L .

DIABETOLOGIA, 2004, 47 (02) :259-265

[8] Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth [J].

Solar, Myriam ;

Cardalda, Carina ;

Houbracken, Isabelle ;

Martin, Merce ;

Angel Maestro, Miguel ;

De Medts, Nele ;

Xu, Xiaobo ;

Grau, Vanessa ;

Heimberg, Harry ;

Bouwens, Luc ;

Ferrer, Jorge .

DEVELOPMENTAL CELL, 2009, 17 (06) :849-860

[9] Growth and regeneration of adult β cells does not involve specialized progenitors [J].

Teta, Monica ;

Rankin, Matthew M. ;

Long, Simon Y. ;

Stein, Geneva M. ;

Kushner, Jake A. .

DEVELOPMENTAL CELL, 2007, 12 (05) :817-826

[10] β cells can be generated from endogenous progenitors in injured adult mouse pancreas [J].

Xu, Xiaobo ;

D'Hoker, Joke ;

Stange, Geert ;

Bonne, Stefan ;

De Leu, Nico ;

Xiao, Xiangwei ;

De Casteele, Mark Van ;

Mellitzer, Georg ;

Ling, Zhidong ;

Pipeleers, Danny ;

Bouwens, Luc ;

Scharfmann, Raphael ;

Gradwohl, Gerard ;

Heimberg, Harry .

CELL, 2008, 132 (02) :197-207