The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor

被引：38

作者：

Flajollet, Sebastien

Lefebvre, Bruno

Cudejko, Celine

Staels, Bart

Lefebvre, Philippe ^{[1
]}

机构：

[1] Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France

[2] INSERM, U545, F-59019 Lille, France

[3] Univ Lille 2, F-59006 Lille, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2007年 / 270卷 / 1-2期

关键词：

transcription; chromatin; nuclear receptors; coactivator;

D O I：

10.1016/j.mce.2007.02.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Retinoic acid receptors (RARs) activate transcription by recruiting coactivator complexes such as histone acetyltransferases (HAT) and the mediator complex, to increase chromatin accessibility by general transcription factors and to promote transcription initiation. Indirect evidences have suggested a role for the ATP-dependent chromatin remodeling complex SWI/SNF in RAR-mediated transcription. Here we demonstrate that two highly related subunits of the core SWI/SNF complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for RARs. This coactivating property is dependent on SRC1 expression, showing that HATs and SWI/SNF cooperate in this retinoid-controlled transcriptional process. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：23 / 32

页数：10

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