The biology of breast carcinoma

被引：137

作者：

Keen, JC ^{[1
]}

Davidson, NE ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

CANCER | 2003年 / 97卷 / 03期

关键词：

D O I：

10.1002/cncr.11126

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The biology of breast carcinoma is complex, with multiple factors contributing to its development and progression. The current review focuses on the role of several critical genes including estrogen receptor, progesterone receptor, retinoic acid receptor-beta, epidermal growth factor receptor family members, p53, BRCA1, and BRCA2 as risk factors for the development of disease, predictors of prognosis and response to therapy, and as therapeutic targets. Studies of the biology of these and other genes that contribute to the development and progression of breast carcinoma have had and will continue to have great impact on all aspects of disease management. (C) 2003 American Cancer Society.

引用

页码：825 / 833

页数：9

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