An elegant mind: Learning and memory in Caenorhabditis elegans

被引:174
作者
Ardiel, Evan L.
Rankin, Catharine H. [1 ]
机构
[1] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
关键词
LONG-TERM-MEMORY; THERMOTACTIC BEHAVIORAL PLASTICITY; REGULATES OLFACTORY ADAPTATION; TAP-WITHDRAWAL RESPONSE; PROTEIN-KINASE-D; C-ELEGANS; GLUTAMATE-RECEPTOR; NEURAL CIRCUIT; SENSORY NEURONS; SYNAPTIC-TRANSMISSION;
D O I
10.1101/lm.960510
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.
引用
收藏
页码:191 / 201
页数:11
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