Organoid Models of Human Gastrointestinal Development and Disease

被引：217

作者：

Dedhia, Priya H. ^{[1
,2
]}

Bertaux-Skeirik, Nina ^{[5
]}

Zavros, Yana ^{[5
]}

Spence, Jason R. ^{[2
,3
,4
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Organogenesis, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Internal Med, Dept Gastroenterol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

[5] Univ Cincinnati, Dept Mol & Cellular Physiol, 231 Albert Sabin Way,4255 MSB, Cincinnati, OH 45267 USA

来源：

GASTROENTEROLOGY | 2016年 / 150卷 / 05期

关键词：

Gut Organoids; Gastrointestinal Development; Gastrointestinal Regeneration; Gastrointestinal Disease; EPIDERMAL-GROWTH-FACTOR; IN-VITRO EXPANSION; INTESTINAL EPITHELIAL-CELLS; PLURIPOTENT STEM-CELLS; TISSUE-ENGINEERED INTESTINE; EX-VIVO CULTURE; CLOSTRIDIUM-DIFFICILE; PANCREAS DEVELOPMENT; SONIC HEDGEHOG; HUMAN-COLON;

D O I：

10.1053/j.gastro.2015.12.042

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for decades in GI research. Organoids are derived from primary tissues and have the capacity for long-term growth. They contain varying levels of cellular complexity and physiological similarity to native organ systems. We review the latest discoveries from studies of tissue-derived and pluripotent stem cell-derived intestinal, gastric, esophageal, liver, and pancreatic organoids. These studies have provided important insights into GI development, tissue homeostasis, and disease and might be used to develop personalized medicines.

引用

页码：1098 / 1112

页数：15

共 172 条

[1]

AN AUTOSOMAL LOCUS CAUSING AUTOIMMUNE-DISEASE - AUTOIMMUNE POLYGLANDULAR DISEASE TYPE-I ASSIGNED TO CHROMOSOME-21 [J].

AALTONEN, J ;

BJORSES, P ;

SANDKUIJL, L ;

PERHEENTUPA, J ;

PELTONEN, L .

NATURE GENETICS, 1994, 8 (01) :83-87

[2]

Modeling human development in 3D culture [J].

Ader, Marius ;

Tanaka, Elly M. .

CURRENT OPINION IN CELL BIOLOGY, 2014, 31 :23-28

[3]

Mutations in Tetratricopeptide Repeat Domain 7A Result in a Severe Form of Very Early Onset Inflammatory Bowel Disease [J].

Avitzur, Yaron ;

Guo, Conghui ;

Mastropaolo, Lucas A. ;

Bahrami, Ehsan ;

Chen, Hannah ;

Zhao, Zhen ;

Elkadri, Abdul ;

Dhillon, Sandeep ;

Murchie, Ryan ;

Fattouh, Ramzi ;

Huynh, Hien ;

Walker, Jennifer L. ;

Wales, Paul W. ;

Cutz, Ernest ;

Kakuta, Yoichi ;

Dudley, Joel ;

Kammermeier, Jochen ;

Powrie, Fiona ;

Shah, Neil ;

Walz, Christoph ;

Nathrath, Michaela ;

Kotlarz, Daniel ;

Puchaka, Jacek ;

Krieger, Jonathan R. ;

Racek, Tomas ;

Kirchner, Thomas ;

Walters, Thomas D. ;

Brumell, John H. ;

Griffiths, Anne M. ;

Rezaei, Nima ;

Rashtian, Parisa ;

Najafi, Mehri ;

Monajemzadeh, Maryam ;

Pelsue, Stephen ;

McGovern, Dermot P. B. ;

Uhlig, Holm H. ;

Schadt, Eric ;

Klein, Christoph ;

Snapper, Scott B. ;

Muise, Aleixo M. .

GASTROENTEROLOGY, 2014, 146 (04) :1028-1039

[4]

Barbera JPM, 2000, DEVELOPMENT, V127, P2433

[5]

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].

Barker, Nick ;

Huch, Meritxell ;

Kujala, Pekka ;

van de Wetering, Marc ;

Snippert, Hugo J. ;

van Es, Johan H. ;

Sato, Toshiro ;

Stange, Daniel E. ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

van den Brink, Stieneke ;

Korving, Jeroen ;

Abo, Arie ;

Peters, Peter J. ;

Wright, Nick ;

Poulsom, Richard ;

Clevers, Hans .

CELL STEM CELL, 2010, 6 (01) :25-36

[6]

Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage [J].

Barrett, Caitlyn W. ;

Reddy, Vishruth K. ;

Short, Sarah P. ;

Motley, Amy K. ;

Lintel, Mary K. ;

Bradley, Amber M. ;

Freeman, Tanner ;

Vallance, Jefferson ;

Ning, Wei ;

Parang, Bobak ;

Poindexter, Shenika V. ;

Fingleton, Barbara ;

Chen, Xi ;

Washington, Mary K. ;

Wilson, Keith T. ;

Shroyer, Noah F. ;

Hill, Kristina E. ;

Burk, Raymond F. ;

Williams, Christopher S. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (07) :2646-2660

[7]

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection [J].

Bartfeld, Sina ;

Bayram, Tulay ;

van de Wetering, Marc ;

Huch, Meritxell ;

Begthel, Harry ;

Kujala, Pekka ;

Vries, Robert ;

Peters, Peter J. ;

Clevers, Hans .

GASTROENTEROLOGY, 2015, 148 (01) :126-U554

[8]

Retinoic Acid Signaling Organizes Endodermal Organ Specification along the Entire Antero-Posterior Axis [J].

Bayha, Elke ;

Jorgensen, Mette C. ;

Serup, Palle ;

Grapin-Botton, Anne .

PLOS ONE, 2009, 4 (06)

[9]

INFLUENCE OF EPIDERMAL GROWTH-FACTOR ON THE MATURATION OF THE FETAL MOUSE DUODENUM IN ORGAN-CULTURE [J].

BEAULIEU, JF ;

MENARD, D ;

CALVERT, R .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1985, 4 (03) :476-481

[10]

TTC7A mutations disrupt intestinal epithelial apicobasal polarity [J].

Bigorgne, Amelie E. ;

Farin, Henner F. ;

Lemoine, Roxane ;

Mahlaoui, Nizar ;

Lambert, Nathalie ;

Gil, Marine ;

Schulz, Ansgar ;

Philippet, Pierre ;

Schlesser, Patrick ;

Abrahamsen, Tore G. ;

Oymar, Knut ;

Davies, E. Graham ;

Ellingsen, Christian Lycke ;

Leteurtre, Emmanuelle ;

Moreau-Massart, Brigitte ;

Berrebi, Dominique ;

Bole-Feysot, Christine ;

Nischke, Patrick ;

Brousse, Nicole ;

Fischer, Alain ;

Clevers, Hans ;

de St Basile, Genevieve .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (01) :328-337

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