Stereoselective reduction of arteannuin B and its chemical transformations

被引：12

作者：

Bhattacharya, AK ^{[1
]}

Pal, M

Jain, DC

Joshi, BS

Roy, R

Rychlewska, U

Sharma, RP

机构：

[1] Cent Inst Med & Aromat Plants, Phytochem Technol Div, PO CIMAP, Lucknow 226015, Uttar Pradesh, India

[2] Cent Drug Res Inst, RSIC Div, Lucknow 226001, Uttar Pradesh, India

[3] Adam Mickiewicz Univ Poznan, Fac Chem, PL-60780 Poznan, Poland

[4] Univ Lucknow, Dept Chem, Lucknow 226007, Uttar Pradesh, India

来源：

TETRAHEDRON | 2003年 / 59卷 / 16期

关键词：

Artemisia annua; antimalarial; artemisinin; arteannuin B; chemical transformations;

D O I：

10.1016/S0040-4020(03)00330-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Absolute stereochemistry of dihydroarteannuin B 5 obtained by the reduction of arteannuin B 3 with Ni2B, NaBH4 or CdCl2-Mg-MeOH-H2O has been established by 2D NMR and single crystal X-ray diffraction studies. Some experiments aimed at the synthesis of dihydrodeoxyarteannuin B [C-4, 5 double bond isomer of 11] are also discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2871 / 2876

页数：6

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