Cerebellum in attention-deficit hyperactivity disorder - A morphometric MRI study

被引:420
作者
Berquin, PC
Giedd, JN
Jacobsen, LK
Hamburger, SD
Krain, AL
Rapoport, JL
Castellanos, FX
机构
[1] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA
[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[3] CHU, Hop Nord, Serv Pediat 1, Amiens, France
[4] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA
关键词
D O I
10.1212/WNL.50.4.1087
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Clinical, neuroanatomic, neurobehavioral, and functional brain-imaging studies suggest a role for the cerebellum in cognitive functions, including attention. However, the cerebellum has not been systematically studied in attention-deficit hyperactivity disorder (ADHD). We quantified the cerebellar and vermal volumes, and the midsagittal areas of three vermal regions, from MRIs of 46 right-handed boys with ADHD and 47 matched healthy controls. Vermal volume was significantly less in the boys with ADHD. This reduction involved mainly the posterior inferior lobe (lobules VIII to X) but not the posterior superior lobe (lobules VI to VII). These results remained significant even after adjustment for brain volume and IQ. A cerebello-thalamo-prefrontal circuit dysfunction may subserve the motor control, inhibition, and executive function deficits encountered in ADHD.
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页码:1087 / 1093
页数:7
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