Ageing of lymphocytes and lymphocytes in the aged

被引：242

作者：

Globerson, A ^{[1
]}

Effros, RB

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[2] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 10期

关键词：

D O I：

10.1016/S0167-5699(00)01714-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations ave reviewed with reference to the importance of integrating information on cellular alterations identified in vitro with data on global physiological changes in the aged environment with which these cells interact in vivo.

引用

页码：515 / 521

页数：7

共 57 条

[1] Thymic atrophy in the mouse is a soluble problem of the thymic environment [J].

Aspinall, R ;

Andrew, D .

VACCINE, 2000, 18 (16) :1629-1637

[2] Immunohistochemical analysis of ageing human B and T cell populations reveals an age-related decline of CD8 T cells in spleen but not gut-associated lymphoid tissue (GALT) [J].

Banerjee, M ;

Sanderson, JD ;

Spencer, J ;

Dunn-Walters, DK .

MECHANISMS OF AGEING AND DEVELOPMENT, 2000, 115 (1-2) :85-99

[3]

BardaSaad M, 1996, EXP HEMATOL, V24, P386

[4] Checkpoints in thymocytopoiesis in aging: expression of the recombination activating genes RAG-1 and RAG-2 [J].

Ben Yehuda, A ;

Friedman, G ;

Wirtheim, E ;

Abel, L ;

Globerson, A .

MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 102 (2-3) :239-247

[5] Efficacy of anti-influenza peptide vaccine in aged mice [J].

Ben-Yedidia, T ;

Abel, L ;

Arnon, R ;

Globerson, A .

MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 104 (01) :11-23

[6] In vitro secretion of cytokines by human bone marrow:: Effects of age and estrogen status [J].

Cheleuitte, D ;

Mizuno, S ;

Glowacki, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (06) :2043-2051

[7] Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow [J].

Chiu, CP ;

Dragowska, W ;

Kim, NW ;

Vaziri, H ;

Yui, J ;

Thomas, TE ;

Harley, CB ;

Lansdorp, PM .

STEM CELLS, 1996, 14 (02) :239-248

[8] Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus-afflicted mice [J].

Dayan, M ;

Segal, R ;

Globerson, A ;

Habut, B ;

Shearer, GM ;

Mozes, E .

EXPERIMENTAL GERONTOLOGY, 2000, 35 (02) :225-236

[9] Changes in thymic function with age and during the treatment of HIV infection [J].

Douek, DC ;

McFarland, RD ;

Keiser, PH ;

Gage, EA ;

Massey, JM ;

Haynes, BF ;

Polis, MA ;

Haase, AT ;

Feinberg, MB ;

Sullivan, JL ;

Jamieson, BD ;

Zack, JA ;

Picker, LJ ;

Koup, RA .

NATURE, 1998, 396 (6712) :690-695

[10] Costimulatory mechanisms in the elderly [J].

Effros, RB .

VACCINE, 2000, 18 (16) :1661-1665

← 1 2 3 4 5 6 →