Circulating biomarkers from tumour bulk to tumour machinery: promises and pitfalls

被引：11

作者：

Gion, M ^{[1
]}

Daidone, MG

机构：

[1] Osped Civile, Ctr Reg Indicatori Biochim Tumore, Assoc ABO, I-30122 Venice, Italy

[2] Ist Nazl Studio & Cura Tumori, Dipartimento Oncol Sperimentale, Unita Operat 10, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2004年 / 40卷 / 17期

关键词：

biomarkers; classification; cancer; pitfalls;

D O I：

10.1016/j.ejca.2004.07.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this paper, we provide a working classification for circulating biomarkers according to their potential clinical application. We broadly divided biomarkers into four groups: (i) biomarkers of cancer risk, (ii) biomarkers of tumour-host interactions, (iii) biomarker of tumour burden, and (iv) function-related biomarkers. We hope this classification will provide a framework to which the results of future studies can be added. We also discuss the promises and pitfalls in the optional use of biomarkers in oncology. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2613 / 2622

页数：10

共 91 条

[1]

Adam BL, 2002, CANCER RES, V62, P3609

[2] Colorectal cancer screening by detection of altered human DNA in stool: Feasibility of a multitarget assay panel [J].

Ahlquist, DA ;

Skoletsky, JE ;

Boynton, KA ;

Harrington, JJ ;

Mahoney, DW ;

Pierceall, WE ;

Thibodeau, SN ;

Shuber, AP .

GASTROENTEROLOGY, 2000, 119 (05) :1219-1227

[3]

Akewanlop C, 2001, CANCER RES, V61, P4061

[4] REVIEW OF SURVIVAL ANALYSES PUBLISHED IN CANCER JOURNALS [J].

ALTMAN, DG ;

DESTAVOLA, BL ;

LOVE, SB ;

STEPNIEWSKA, KA .

BRITISH JOURNAL OF CANCER, 1995, 72 (02) :511-518

[5] DANGERS OF USING OPTIMAL CUTPOINTS IN THE EVALUATION OF PROGNOSTIC FACTORS [J].

ALTMAN, DG ;

LAUSEN, B ;

SAUERBREI, W ;

SCHUMACHER, M .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (11) :829-835

[6] Detecting lung cancer in plasma with the use of multiple genetic markers [J].

Andriani, F ;

Conte, D ;

Mastrangelo, T ;

Leon, M ;

Ratcliffe, C ;

Roz, L ;

Pelosi, G ;

Goldstraw, P ;

Sozzi, G ;

Pastorino, U .

INTERNATIONAL JOURNAL OF CANCER, 2004, 108 (01) :91-96

[7] Functional relationship and gene ontology classification of breast cancer biomarkers [J].

Arciero, C ;

Somiari, SB ;

Shriver, CD ;

Brzeski, H ;

Jordan, R ;

Hue, H ;

Ellsworth, DL ;

Somiari, RI .

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2003, 18 (04) :241-272

[8]

Bearzatto A, 2002, CLIN CANCER RES, V8, P3782

[9] Flexible modelling in survival analysis. Structuring biological complexity from the information provided by tumor markers [J].

Biganzoli, E ;

Boracchi, P ;

Daidone, MG ;

Gion, M ;

Marubini, E .

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 1998, 13 (03) :107-123

[10]

Bossuyt PM, 2003, CLIN BIOCHEM, V36, P2

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