Production of monocyte chemoattractant protein 1 in tuberculosis patients

被引：69

作者：

Lin, YG

Gong, JH

Zhang, M

Xue, WF

Barnes, PF

机构：

[1] Univ Texas, Ctr Hlth, Ctr Pulm & Infect Dis Control, Tyler, TX 75710 USA

[2] Univ Texas, Ctr Hlth, Dept Cell Biol, Tyler, TX 75710 USA

[3] Univ Texas, Ctr Hlth, Dept Med, Tyler, TX 75710 USA

[4] Univ So Calif, Sch Med, Dept Med, Los Angeles, CA 90033 USA

[5] Nanjing Med Univ, Dept Pathol, Nanjing, Peoples R China

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 05期

关键词：

D O I：

10.1128/IAI.66.5.2319-2322.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14(+) blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14(+) monocytes from healthy tuberculin reactors. MCP-1. production in lymph nodes from tuberculosis patients was also markedly increased. These findings suggest that MCP-1 can contribute to the antimycobacterial inflammatory response by attracting monocytes and T lymphocytes.

引用

页码：2319 / 2322

页数：4

共 11 条

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