Hypotensive effect of γ-glutamylmethylamide in spontaneously hypertensive rats

被引：69

作者：

Yokogoshi, H ^{[1
]}

Kobayashi, M ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Lab Nutr Biochem, Shizuoka 422, Japan

来源：

LIFE SCIENCES | 1998年 / 62卷 / 12期

关键词：

gamma-glutamylmethylamide; hypotension; blood pressure; SHR; green tea;

D O I：

10.1016/S0024-3205(98)00029-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of gamma-glutamylmethylamide(GMA), one of the components of green tea extract, on the blood pressure in spontaneously hypertensive rats (SHR) was investigated. The effect of glutamic acid and r-glutamylethylamide (theanine), which is structually similar to GMA, was also examined. When SHR were injected with glutamic acid (2000mg/kg), the blood pressure was not altered. The same dose of theanine decreased it significantly. GMA administration to SHR reduced the blood pressure significantly, and its degree of hypotensive action was more effective than that by theanine administration.

引用

页码：1065 / 1068

页数：4

共 12 条

[1] BRAIN AMINES AND MODELS OF EXPERIMENTAL HYPERTENSION [J].

CHALMERS, JP .

CIRCULATION RESEARCH, 1975, 36 (04) :469-480

[2] MULTIPLE RANGE TESTS FOR CORRELATED AND HETEROSCEDASTIC MEANS [J].

DUNCAN, DB .

BIOMETRICS, 1957, 13 (02) :164-176

[3]

Hara Y., 1990, Journal of Japanese Society of Nutrition and Food Science [Nihon Eiyo Shokuryo Gakkai-shi], V43, P345

[4]

KONISHI S, 1970, CHAGYO KENKYO HOKOKU, V2, P22

[5] REVIEW OF THE ROLE OF THE CENTRAL SEROTONERGIC NEURONAL SYSTEM IN BLOOD-PRESSURE REGULATION [J].

KUHN, DM ;

WOLF, WA ;

LOVENBERG, W .

HYPERTENSION, 1980, 2 (03) :243-255

[6]

NEIMS AH, 1983, NUTR BRAIN, P1

[7]

OMORI M, 1987, NIPPON NOGEIK KAISHI, V61, P1449

[8]

Sakato Y., 1949, NIPPON NOGEIKAGAKU K, V23, P262, DOI DOI 10.1271/NOGEIKAGAKU1924.23.262

[9] TYROSINE ADMINISTRATION REDUCES BLOOD-PRESSURE AND ENHANCES BRAIN NOREPINEPHRINE RELEASE IN SPONTANEOUSLY HYPERTENSIVE RATS [J].

SVED, AF ;

FERNSTROM, JD ;

WURTMAN, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (07) :3511-3514

[10]

VONZWIETEN PA, 1975, PROG PHARMACOL, V1, P1

← 1 2 →