共 52 条
Sclerosing cholangitis
被引:14
作者:

Maggs, James R. L.
论文数: 0 引用数: 0
h-index: 0
机构:
John Radcliffe Hosp, Dept Gastroenterol, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Gastroenterol, Oxford OX3 9DU, England

Chapman, Roger W.
论文数: 0 引用数: 0
h-index: 0
机构:
John Radcliffe Hosp, Dept Gastroenterol, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Gastroenterol, Oxford OX3 9DU, England
机构:
[1] John Radcliffe Hosp, Dept Gastroenterol, Oxford OX3 9DU, England
关键词:
cholangiocarcinoma;
orthotopic liver transplantation;
primary sclerosing cholangitis;
ursodeoxycholic acid;
D O I:
10.1097/MOG.0b013e32805867e6
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Purpose of review Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by strictures of the biliary tree complicated by cirrhosis and cholangiocarcinoma. It is immune mediated, although the precise aetiology remains unknown. Recent findings Research into etiopathogenesis and epidemiology, diagnosis of cholangiocarcinoma, associations with inflammatory bowel disease and autoimmune pancreatitis, and medical therapy are discussed. Summary Multiple gene polymorphisms associated with primary sclerosing cholangitis have been investigated. Common inflammatory bowel disease-associated polymorphisms do not confer any susceptibility to primary sclerosing cholangitis; the role of intercellular adhesion molecule-1 gene polymorphisms and CCR5 mutations remain unclear. Elevated IgG4 has been demonstrated in a subgroup of primary sclerosing cholangitis patients, which may indicate an overlap with autoimmune pancreatitis and possible responsiveness to steroids. Biliary brush cytology may assist in diagnosis of cholangiocarcinoma, although further clinical indicators are required. Animal studies suggest the superiority of 24-norursocleoxycholic acid over ursodeoxycholic acid in reducing histological disease progress; translational studies in humans are now required.
引用
收藏
页码:310 / 316
页数:7
相关论文
共 52 条
[1]
Sclerosing cholangitis: A focus on secondary causes
[J].
Abdalian, Rupert
;
Heathcote, E. Jenny
.
HEPATOLOGY,
2006, 44 (05)
:1063-1074

Abdalian, Rupert
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hlth Network, Toronto Western Hosp, Dept Med, Toronto, ON M5T 2S8, Canada Univ Toronto, Hlth Network, Toronto Western Hosp, Dept Med, Toronto, ON M5T 2S8, Canada

Heathcote, E. Jenny
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Hlth Network, Toronto Western Hosp, Dept Med, Toronto, ON M5T 2S8, Canada Univ Toronto, Hlth Network, Toronto Western Hosp, Dept Med, Toronto, ON M5T 2S8, Canada
[2]
Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
[J].
Adams, DH
;
Eksteen, B
.
NATURE REVIEWS IMMUNOLOGY,
2006, 6 (03)
:244-251

Adams, DH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Birmingham, Sch Med, Inst Biomed Res, Liver Res Labs,MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Med, Inst Biomed Res, Liver Res Labs,MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

Eksteen, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Birmingham, Sch Med, Inst Biomed Res, Liver Res Labs,MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England Univ Birmingham, Sch Med, Inst Biomed Res, Liver Res Labs,MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England
[3]
Chemotherapy-induced sclerosing cholangitis: Long-term response to endoscopic therapy
[J].
Alazmi, WM
;
McHenry, L
;
Watkins, JL
;
Fogel, EL
;
Schmidt, S
;
Sherman, S
;
Lehman, GL
.
JOURNAL OF CLINICAL GASTROENTEROLOGY,
2006, 40 (04)
:353-357

Alazmi, WM
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

McHenry, L
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

Watkins, JL
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

Fogel, EL
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

Schmidt, S
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

Sherman, S
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA

Lehman, GL
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA Indiana Univ, Med Ctr, Indianapolis, IN 46202 USA
[4]
Is there a role for cholangioscopy in patients with primary sclerosing cholangitis?
[J].
Awadallah, NS
;
Chen, YK
;
Piraka, C
;
Antillon, MR
;
Shah, RJ
.
AMERICAN JOURNAL OF GASTROENTEROLOGY,
2006, 101 (02)
:284-291

Awadallah, NS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA

Chen, YK
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA

Piraka, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA

Antillon, MR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA

Shah, RJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Dept Internal Med, Denver, CO USA
[5]
Primary sclerosing cholangitis can present with acute liver failure:: Report of two cases
[J].
Bergquist, A
;
Glaumann, H
;
Lindberg, B
;
Broomé, U
.
JOURNAL OF HEPATOLOGY,
2006, 44 (05)
:1005-1008

Bergquist, A
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol, Stockholm, Sweden

Glaumann, H
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol, Stockholm, Sweden

Lindberg, B
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol, Stockholm, Sweden

Broomé, U
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol, Stockholm, Sweden
[6]
Perinatal events and the risk of developing primary sclerosing cholangitis
[J].
Bergquist, Annika
;
Montgomery, Scott M.
;
Lund, Ulrika
;
Ekbom, Anders
;
Olsson, Rolf
;
Lindgren, Stefan
;
Prytz, Hanne
;
Hultcrantz, Rolf
;
Broome, Ulrika
.
WORLD JOURNAL OF GASTROENTEROLOGY,
2006, 12 (37)
:6037-6040

Bergquist, Annika
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Montgomery, Scott M.
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Lund, Ulrika
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Ekbom, Anders
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Olsson, Rolf
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Lindgren, Stefan
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Prytz, Hanne
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Hultcrantz, Rolf
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden

Broome, Ulrika
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Univ Hosp, Karolinska Inst, Dept Gastroenterol & Hepatol, Stockholm, Sweden
[7]
Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis
[J].
Berstad, AE
;
Aabakken, L
;
Smith, HJ
;
Aasen, S
;
Boberg, KM
;
Schrumpf, E
.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,
2006, 4 (04)
:514-520

Berstad, AE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway

Aabakken, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway

Smith, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway

Aasen, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway

Boberg, KM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway

Schrumpf, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp, Rikshosp, Dept Radiol, Gastroenterol Sect, N-0027 Oslo, Norway
[8]
Liver transplantation in primary sclerosing cholangitis
[J].
Bjoro, Kristian
;
Brandsaeter, Bjorn
;
Foss, Aksel
;
Schrumpf, Erik
.
SEMINARS IN LIVER DISEASE,
2006, 26 (01)
:69-79

Bjoro, Kristian
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Hosp Norway, Dept Med, N-0027 Oslo, Norway Natl Hosp Norway, Dept Med, N-0027 Oslo, Norway

Brandsaeter, Bjorn
论文数: 0 引用数: 0
h-index: 0
机构: Natl Hosp Norway, Dept Med, N-0027 Oslo, Norway

Foss, Aksel
论文数: 0 引用数: 0
h-index: 0
机构: Natl Hosp Norway, Dept Med, N-0027 Oslo, Norway

Schrumpf, Erik
论文数: 0 引用数: 0
h-index: 0
机构: Natl Hosp Norway, Dept Med, N-0027 Oslo, Norway
[9]
Diagnostic benefit of biliary brush cytology in cholangiocarcinoma in primary sclerosing cholangitis
[J].
Boberg, Kirsten Muri
;
Jebsen, Peter
;
Clausen, Ole Petter
;
Foss, Aksel
;
Aabakken, Lars
;
Schrumpf, Erik
.
JOURNAL OF HEPATOLOGY,
2006, 45 (04)
:568-574

Boberg, Kirsten Muri
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway

Jebsen, Peter
论文数: 0 引用数: 0
h-index: 0
机构: Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway

Clausen, Ole Petter
论文数: 0 引用数: 0
h-index: 0
机构: Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway

Foss, Aksel
论文数: 0 引用数: 0
h-index: 0
机构: Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway

Aabakken, Lars
论文数: 0 引用数: 0
h-index: 0
机构: Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway

Schrumpf, Erik
论文数: 0 引用数: 0
h-index: 0
机构: Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway
[10]
Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
[J].
Bowlus, Christopher L.
;
Karlsen, Tom H.
;
Broome, Ulrika
;
Thorsby, Erik
;
Vatn, Morten
;
Schrumpf, Erik
;
Lie, Benedicte A.
;
Boberg, Kirsten Muri
.
JOURNAL OF HEPATOLOGY,
2006, 45 (05)
:704-710

Bowlus, Christopher L.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Karlsen, Tom H.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Broome, Ulrika
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Thorsby, Erik
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Vatn, Morten
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Schrumpf, Erik
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Lie, Benedicte A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway

Boberg, Kirsten Muri
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway