New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes

被引：60

作者：

Dalton, CM

Brex, PA

Miszkiel, KA

Fernando, K

MacManus, DG

Plant, GT

Thompson, AJ

Miller, DH

机构：

[1] Natl Hosp Neurol & Neurosurg, Inst Neurol, NMR Res Unit, London WC1N 3BG, England

[2] Natl Hosp Neurol & Neurosurg, Lysholm Dept Neuroradiol, London WC1N 3BG, England

[3] Moorfields Eye Hosp, London, England

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 05期

关键词：

D O I：

10.1002/ana.10580

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium-enhancing lesions for dissemination in time at a 3-month follow-up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients.

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页码：673 / 676

页数：4

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