Changes in estrogen-α receptor immunoreactivity during the estrous cycle in lactating dairy cattle

被引:15
作者
van Eerdenburg, FJCM
Daemen, IAJJM
van der Beek, EM
van Leeuwen, FW
机构
[1] Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, NL-3584 CL Utrecht, Netherlands
[2] Wageningen Univ, Dept Anim Sci, Human & Anim Physiol Grp, NL-6709 PJ Wageningen, Netherlands
[3] Netherlands Inst Brain Res, NL-1105 AZ Amsterdam, Netherlands
关键词
hypothalamus; bovine; sexual behavior; estradiol; regulation;
D O I
10.1016/S0006-8993(00)02870-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Estradiol is one of the most important hormones in the regulation of estrous behavior, which is at a very low level of expression in the modern dairy cow. In the present study the neuroanatomical distribution of estrogen receptors of the alpha -subtype (ER-alpha) in the bovine hypothalamic area is determined with immunocytochemical methods, at various stages of the estrous cycle. During the luteal phase of the cycle, ER-alpha immunoreactive cells were found in most of the nuclei that are known to express ER-alpha immunoreactivity in other species, like the Bed nucleus of the Stria terminalis, Medial preoptic area, Ventromedial hypothalamus and Arcuate nucleus. During estrus and metestrus, however, no ER-alpha immunoreactive cells could be detected in those areas, except for a few in the caudal Arcuate nucleus. The results from the present study indicate that there is a coherent regulation and timing of physiological and behavioral events around ovulation, in which estradiol and its receptor play a key role. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:219 / 223
页数:5
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