Bacterial adherence to silver nitrate coated poly-L-lactic acid urological stents in vitro

被引：15

作者：

Multanen, M

Talja, M

Hallanvuo, S

Siitonen, A

Välimaa, T

Tammela, TLJ

Seppälä, J

Törmälä, P

机构：

[1] Paijat Hame Cent Hosp, Dept Surg, Div Urol, FIN-15850 Lahti, Finland

[2] Natl Publ Hlth Inst, Lab Enter Pathogens, Helsinki, Finland

[3] Tampere Univ Technol, Inst Biomat, FIN-33101 Tampere, Finland

[4] Tampere Univ Hosp, Div Urol, Tampere, Finland

[5] Helsinki Univ Technol, FIN-02150 Espoo, Finland

来源：

UROLOGICAL RESEARCH | 2000年 / 28卷 / 05期

关键词：

biodegradation; infection; urology; stents;

D O I：

10.1007/s002400000133

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this study was to see whether it is possible to prevent bacterial adherence to bioabsorbable self-reinforced L-lactic acid polymer (SR-PLLA) urological stents. The SR-PLLA stents were coated with silver nitrate blended epsilon -caprolactone/L-lactide copolymer. The adherence of five bacterial strains (Pseudomonas aeruginosa, Enterococcus faecalis, Proteus mirabilis and two strains of Escherichia coli) to coated and non-coated SR-PLLA wires were tested. It was found that silver nitrate coating prevented the adherence of bacteria (except E. faecalis) to SR-PLLA stents. The preventive effect correlated with the silver nitrate concentration. It was also found that silver nitrate coating reduced the amount of bacteria in ambient urine. In conclusion, silver nitrate coating may reduce stent-associated bacterial infections by preventing the adherence of bacteria. Further studies are needed to confirm its efficacy and safety in clinical practice.

引用

页码：327 / 331

页数：5

共 18 条

[1] TESTING THE SUSCEPTIBILITY OF BACTERIA IN BIOFILMS TO ANTIBACTERIAL AGENTS [J].