Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas

被引：62

作者：

Nagai, H

Naka, T

Terada, Y

Komazaki, T

Yabe, A

Jin, EJ

Kawanami, O

Kishimoto, T

Konishi, N

Nakamura, M

Kobayashi, Y

Emi, M

机构：

[1] Nippon Med Coll, Dept Mol Biol & Pathol, Inst Gerontol, Nakahara Ku, Kawasaki, Kanagawa 2110063, Japan

[2] Osaka Univ, Sch Med, Dept Med 3, Osaka, Japan

[3] Nara Med Univ, Dept Pathol, Kashihara, Nara 634, Japan

[4] Saitama Canc Ctr Hosp, Dept Pathol, Saitama, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2003年 / 48卷 / 02期

关键词：

hepatoblastoma; SSI-1/SOCS-1/JAB; methylation; JAK/STAT; hepatocellular carcinoma;

D O I：

10.1007/s100380300008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We recently demonstrated inactivation in hepatocellular carcinomas (HCCs) of the gene encoding SOCS1/ JAB1/SSI-1, a JAK-binding protein that regulates the JAK/STAT signal-transduction pathway. In a follow-up immunochemical investigation of expression of SOCS-1 in hepatoblastomas (HBLs), the protein was markedly reduced in half of the HBL tumors we examined. CpG-rich regions upstream of the SOCS-1 gene were hypermehylated in 7 of the 15 HBL cases. The results suggest that hypermethylation may play an important role in silencing the SOCS-1 gene, not only in adult HCCs, but also in liver tumors arising in childhood.

引用

页码：65 / 69

页数：5

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