The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system

被引：12

作者：

Joyce, JN ^{[1
]}

Yoshimoto, K

Ueda, S

机构：

[1] Sun Hlth Res Inst, Thomas H Christopher Ctr Parkinsons Dis Res, Sun City, AZ 85351 USA

[2] Kyoto Prefectural Univ Med, Dept Legal Med, Kamikyo Ku, Kyoto 6010841, Japan

[3] Dokkyo Univ, Sch Med, Dept Histol & Neurobiol, Mibu, Tochigi 3210293, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 10期

关键词：

nucleus accumbens; Parkinson's disease; radioligand assay; striatum; tyrosine hydroxylase;

D O I：

10.1097/00001756-200007140-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experimental studies of the regulation of the dopamine (DA) D-3 receptor have utilized techniques causing massive depletions of the DA system. Zitter mutant rats exhibiting a heterogeneous loss of striatal DA innervation were examined for DA transporter (DAT) binding and DA D-3 receptor number by autoradiography and compared with Sprague-Dawley rats. A significant loss of DAT binding was observed with the greatest in the lateral caudate-putamen (72% loss) and the least in the nucleus accumbens (45% loss). DA D-3 receptors were reduced by >70% in all regions, even in the nucleus accumbens that exhibited considerably smaller depletions of DAT binding, indicating that loss of D-3 receptors may occur prior to massive loss of DA innervation. NeuroReport 11:2173-2175 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：2173 / 2175

页数：3

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