Clinical correlates of brain morphometric features of subjects with low-functioning autistic disorder

被引:39
作者
Elia, M
Ferri, R
Musumeci, SA
Panerai, S
Bottitta, M
Scuderi, C
机构
[1] OASI Inst, Dept Neurol, I-94018 Troina, Italy
[2] IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Dept Psychol, Troina, Italy
关键词
D O I
10.1177/088307380001500802
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Numerous neuropathologic and imaging studies have reported different structural abnormalities in the brains of autistic subjects. However, whether or not the degree of brain abnormality is correlated with the severity of developmental impairment in autistic disorder is still unknown. The midsagittal area of the cerebrum, corpus callosum, midbrain, cerebellar vermis, and vermal lobules VI and VII was measured by means of magnetic resonance imaging in 22 boys with low-functioning autistic disorder and in 11 age-matched normal controls. Morphometric measures were statistically compared between groups and correlated with age and scores on the Psychoeducational Profile-Revised and the Childhood Autism Rating Scale. A significant negative correlation was found between midsagittal area of the cerebrum and age in patients with autistic disorder, and a positive correlation was found between the midsagittal area of the midbrain and some subscales of the Psychoeducational Profile-Revised.
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收藏
页码:504 / 508
页数:5
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