Myocardial and plasma renin-angiotensinogen dynamics during pressure-induced cardiac hypertrophy

被引:42
作者
Heller, LJ
Opsahl, JA
Wernsing, SE
Saxena, R
Katz, SA
机构
[1] Univ Minnesota, Sch Med, Dept Physiol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Dept Med & Mol Physiol, Duluth, MN 55812 USA
[3] Hennepin Cty Med Ctr, Div Nephrol, Minneapolis, MN 55415 USA
[4] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA
关键词
renin-angiotensin system; myocardium; hypertension; aortic constriction; cardiac myocytes;
D O I
10.1152/ajpregu.1998.274.3.R849
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Plasma and left ventricular (LV) renin and angiotensinogen concentrations were assessed in a rat model of pressure-overload cardiac hypertrophy to determine if myocardial levels remained proportional to plasma levels over time. Three days after subdiaphragmatic aortic constriction (AC), LV hypertrophy was evident and renin concentrations in both plasma and LV, although not significantly elevated, were positively correlated with relative cardiac mass. After 42 days AC, LV hypertrophy remained, plasma and LV renin and angiotensinogen levels were not different from shams, and there was no correlation between renin and relative cardiac mass. Furthermore, LV renin and angiotensinogen concentrations remained at similar to 25 and 4%, respectively, of those in plasma throughout the experiment. Myocytes from 3-day AC and sham-treated rats contained little renin as did LV from 48-h anephric rats. Incubations using calculated concentrations of myocardial interstitial renin and angiotensinogen revealed significant angiotensin I generation. These data suggest that LV renin in this model varies directly with plasma renin, is confined to the interstitial space, and can generate significant intramyocardial angiotensin I.
引用
收藏
页码:R849 / R856
页数:8
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