RNA AIDs DNA

被引：15

作者：

Fugmann, SD

Schatz, DG

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1038/ni0503-429

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experiments based on the requirement for immunoglobulin gene transcription provide new insights into the elusive role played by AID in immunoglobulin class switching and hypermutation.

引用

页码：429 / 430

页数：2

共 12 条

[1] Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase [J].

Bransteitter, R ;

Pham, P ;

Scharff, MD ;

Goodman, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :4102-4107

[2] Transcription-targeted DNA deamination by the AID antibody diversification enzyme [J].

Chaudhuri, J ;

Tian, M ;

Khuong, C ;

Chua, K ;

Pinaud, E ;

Alt, FW .

NATURE, 2003, 422 (6933) :726-730

[3] Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase [J].

Di Noia, J ;

Neuberger, MS .

NATURE, 2002, 419 (6902) :43-48

[4]

DICKERSON SK, 2003, IN PRESS J EXP MED

[5]

EOI T, 2003, P NATL ACAD SCI USA, V100, P2634

[6] Molecular mechanism of class switch recombination: Linkage with somatic hypermutation [J].

Honjo, T ;

Kinoshita, K ;

Muramatsu, M .

ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :165-196

[7] Mechanism and control of class-switch recombination [J].

Manis, JP ;

Tian, M ;

Alt, FW .

TRENDS IN IMMUNOLOGY, 2002, 23 (01) :31-39

[8] Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells [J].

Muramatsu, M ;

Sankaranand, VS ;

Anant, S ;

Sugai, M ;

Kinoshita, K ;

Davidson, NO ;

Honjo, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18470-18476

[9] Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice [J].

Rada, C ;

Williams, GT ;

Nilsen, H ;

Barnes, DE ;

Lindahl, T ;

Neuberger, MS .

CURRENT BIOLOGY, 2002, 12 (20) :1748-1755

[10]

RAMIRO AR, 2003, RAMIRO AROL, V4, P452

← 1 2 →