p53 and apoptosis: It's not just in the nucleus anymore

被引：53

作者：

Manfredi, JJ ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Donald H Ruttenberg Canc Ctr, New York, NY 10029 USA

来源：

MOLECULAR CELL | 2003年 / 11卷 / 03期

关键词：

D O I：

10.1016/S1097-2765(03)00106-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.

引用

页码：552 / 554

页数：3

共 7 条

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