Perspective - Emerging challenges in regulatory T cell function and biology

被引：190

作者：

Sakaguchi, Shimon ^{[1
]}

Powrie, Fiona

机构：

[1] Kyoto Univ, Dept Expt Pathol, Inst Frontier Med Sci, Kyoto 6068507, Japan

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SCIENCE | 2007年 / 317卷 / 5838期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.1142331

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Much progress has been made in understanding how the immune system is regulated, with a great deal of recent interest in naturally occurring CD4(+) regulatory T cells that actively engage in the maintenance of immunological self-tolerance and immune homeostasis. The challenge ahead for immunologists is the further elucidation of the molecular and cellular processes that govern the development and function of these cells. From this, exciting possibilities are emerging for the manipulation of regulatory T cell pathways in treating immunological diseases and suppressing or augmenting physiological immune responses.

引用

页码：627 / 629

页数：3

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