Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

被引：65

作者：

Salmena, Leonardo

Pandolfi, Pier Paolo ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Dept Pathol, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 06期

关键词：

D O I：

10.1038/nrc2145

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have shown that three major tumour-suppressor proteins undergo monoubiquitylation-mediated nuclear-cytoplasmic shuttling. Importantly, this mechanism has consequences for cancer and implies that proper localization is central to the function of tumour suppressors. This Progress article highlights recent efforts demonstrating that monoubiquitylation coupled to nuclear-cytoplasmic shuttling might be a novel regulatory mechanism that directly influences the function of tumour suppressors.

引用

页码：409 / 413

页数：5

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