Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus

被引：14

作者：

Haring, JS

Perlman, S ^{[1
]}

机构：

[1] Univ Iowa, Dept Pediat, Med Labs 2042, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 137卷 / 1-2期

关键词：

T lymphocytes; cell trafficking; viral; demyelination; transgenic/knockout;

D O I：

10.1016/S0165-5728(03)00041-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Demyelination following infection of mice with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV) is immune-mediated. It has been demonstrated that MHV-specific CD4 and CD8 T cells are capable of causing demyelination independent of the other T cell subset. Recent work has also demonstrated that activated bystander CD8 T cells mediate significant demyelination. The ability of bystander CD4 T cells to mediate demyelination was investigated using CD4 T cell transgenic mice. The results indicated that bystander CD4 T cells were unable to cause demyelination in MHV-infected mice, despite being recruited into the central nervous system (CNS) and irrespective of activation status. These results suggest that CD4 T cells must recognize antigen in the CNS in order to cause demyelination. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：42 / 50

页数：9

共 42 条

[1] T-cell apoptosis in inflammatory brain lesions - Destruction of T cells does not depend on antigen recognition [J].