Treatment of postkeratitis fusarium endophthalmitis with amphotericin B lipid complex

被引:26
作者
Goldblum, D
Frueh, BE
Zimmerli, S
Böhnke, M
机构
[1] Univ Bern, Dept Ophthalmol, CH-3010 Bern, Switzerland
[2] Univ Bern, Inst Med Microbiol, CH-3010 Bern, Switzerland
关键词
eye; fungus; Fusarium; keratitis; endophthalmitis; amphotericin B; amphotericin B lipid complex (ABLC);
D O I
10.1097/00003226-200011000-00019
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose. The authors report the first case of Fusarium solani keratitis that progressed to fungal endophthalmitis and was successfully treated with amphotericin B lipid complex (ABLC). Method, The case of a 34-year-old immunocompetent woman who developed a contact lens-related F. solani keratitis requiring emergency penetrating keratoplasty (PKP) was analyzed. The immunocompetent patient developed fungal endophthalmitis (anterior chamber tap positive for F. solani three months after PKP) and was eventually treated with ABLC. Results. Systemic amphotericin B (total, 0.42 g) and ketoconazole in addition to topical natamycin and amphotericin did not prove to be effective in eradicating the mycosis in the anterior chamber. Under ABLC treatment (total, 8.79 g), the anterior chamber inflammation resolved completely. No recurrence was observed during an Ii-month followup after treatment was discontinued. Conclusion. ABLC proved to be effective in treating F. solani endophthalmitis. It is an important addition to the ophthalmic armamentarium, and appeared to be a better therapeutic agent than standard amphotericin B in this patient.
引用
收藏
页码:853 / 856
页数:4
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