Mosaic organization of neural stem cells in the adult brain

被引：627

作者：

Merkle, Florian T.

Mirzadeh, Zaman

Alvarez-Buylla, Arturo ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dev & Stem Cell Biol Program, San Francisco, CA 94143 USA

来源：

SCIENCE | 2007年 / 317卷 / 5836期

关键词：

D O I：

10.1126/science.1144914

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The in vivo potential of neural stem cells in the postnatal mouse brain is not known, but because they produce many different types of neurons, they must be either very versatile or very diverse. By specifically targeting stem cells and following their progeny in vivo, we showed that postnatal stem cells in different regions produce different types of neurons, even when heterotopically grafted or grown in culture. This suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors.

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页码：381 / 384

页数：4

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