Portal Fibroblasts: Underappreciated Mediators of Biliary Fibrosis

被引：206

作者：

Dranoff, Jonathan A. ^{[1
]}

Wells, Rebecca G. ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Dept Med, Sect Digest Dis, New Haven, CT 06520 USA

[2] Univ Penn, Sch Med, Dept Med, Div Gastroenterol, Philadelphia, PA 19104 USA

来源：

HEPATOLOGY | 2010年 / 51卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HEPATIC STELLATE CELLS; EXTRACELLULAR-MATRIX DEPOSITION; SINUSOIDAL ENDOTHELIAL-CELLS; RAT-LIVER MYOFIBROBLASTS; NECROSIS-FACTOR-ALPHA; TISSUE GROWTH-FACTOR; BILE-DUCT EPITHELIA; MESENCHYMAL CELLS; CHOLESTATIC FIBROSIS; INCREASED EXPRESSION;

D O I：

10.1002/hep.23405

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the setting of chronic injury to fibrogenic myofibroblasts, playing an important role in collagen production in the fibrotic liver. Portal fibroblasts (PFs) are located adjacent to bile duct epithelia and thus play a particularly significant role in biliary fibrosis. New data suggest that they may also have key functions independent of fibrogenesis. This review addresses the definition and characteristics of PFs as well as their signaling pathways, interactions with the biliary epithelium, and contributions to liver pathobiology. Conclusion: PFs are an important and multifunctional nonparenchymal cell population in need of further study. (HEPATOLOGY 2010;51:1438-1444.)

引用

页码：1438 / 1444

页数：7

共 67 条

[1] Connective tissue growth factor in human liver cirrhosis [J].

Abou-Shady, M ;

Friess, H ;

Zimmermann, A ;

di Mola, FF ;

Guo, XZ ;

Baer, HU ;

Büchler, MW .

LIVER, 2000, 20 (04) :296-304

[2] The pathobiology of biliary epithelia [J].

Alpini, G ;

McGill, JM ;

LaRusso, NF .

HEPATOLOGY, 2002, 35 (05) :1256-1268

[3] Mesenchymal Origin of Hepatic Stellate Cells, Submesothelial Cells, and Perivascular Mesenchymal Cells During Mouse Liver Development [J].

Asahina, Kinji ;

Tsai, Shirley Y. ;

Li, Peng ;

Ishii, Mamoru ;

Maxson, Robert E., Jr. ;

Sucov, Henry M. ;

Tsukamoto, Hidekau .

HEPATOLOGY, 2009, 49 (03) :998-1011

[4] Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries [J].

Beaussier, Marc ;

Wendum, Dominique ;

Schiffer, Eduardo ;

Dumont, Sylvie ;

Rey, Colette ;

Lienhart, Andre ;

Housset, Chantal .

LABORATORY INVESTIGATION, 2007, 87 (03) :292-303

[5] MONOCYTE CHEMOATTRACTANT PROTEIN-1 ACTS AS A T-LYMPHOCYTE CHEMOATTRACTANT [J].

CARR, MW ;

ROTH, SJ ;

LUTHER, E ;

ROSE, SS ;

SPRINGER, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3652-3656

[6]

CARRUTHERS JOHN S., 1962, EXPTL AND MOLECULAR PATHOL, V1, P377, DOI 10.1016/0014-4800(62)90032-1

[7] Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers [J].

Cassiman, D ;

Libbrecht, L ;

Desmet, V ;

Denef, C ;

Roskams, T .

JOURNAL OF HEPATOLOGY, 2002, 36 (02) :200-209

[8] Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research [J].

Cassiman, D ;

Roskams, T .

JOURNAL OF HEPATOLOGY, 2002, 37 (04) :527-535

[9] Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis [J].

Clouston, AD ;

Powell, EE ;

Walsh, MJ ;

Richardson, MM ;

Demetris, AJ ;

Jonsson, JR .

HEPATOLOGY, 2005, 41 (04) :809-818

[10]

Desmouliere A, 1997, LAB INVEST, V76, P765

← 1 2 3 4 5 6 7 →